Up to 56% of people attempting Celexa withdrawal or coming off other antidepressants experience an antidepressant withdrawal syndrome.
This is sometimes called Celexa discontinuation syndrome. 46% of those who experience withdrawal describe the symptoms as severe.6
Adverse events from good diet, exercise, & lifestyle changes? None.
Alternative to Meds has been an antidepressant withdrawal help authority for over 15 years. We would like you to review our published evidence regarding Alternative to Meds Center’s remarkable Celexa withdrawal success. Even with what some might consider the most strange or bizarre symptoms, these same symptoms are, unfortunately, not at all uncommon in the clients who come to us for help. We understand. Not only do we specialize in resolving these symptoms, but many of us have also had to endure them ourselves in order to become the teachers that we are.
Watch this video of a woman who overcame incredible odds and liabilities to get off of antidepressants and benzos. On entry to the program, she was barely able to walk and highly symptomatic on the medications. Not only did she get back a life worth living, but she went on to be a therapist helping people in similar ways.
15 Years Experience by Professionals Who Understand Your Journey.
With proper guidance and preparation in place, a person does not have to suffer unnecessarily harsh and lingering symptoms of Celexa withdrawal. Without preparation and guidance for navigating a gradual reduction, Celexa withdrawals can oscillate from moderate to severe and debilitating.
Celexa Withdrawal Symptoms include:
Suicidality.28,29
Deep depression.28
Dizziness.16
Agitation, aggression, mood swings.16
Loss of appetite.30
Hostility.16
Sensory disturbances, hallucinations of sound, sight, touch, taste, etc.16
Brain zaps, electrical shock sensations in the head and neck, and or spine*16
Dysphoria, a profound sense of unease, unhappiness, and dissatisfaction with life.16
Physical aches, pains, cramps, tingling, or other unwanted physical sensations.
Sleep disruptions, insomnia.16
Loss of interest in usual socializing, hobbies, and past activities that were enjoyed.28
*The FDA label (page 34) for Celexa warns that electric-shock-like sensations may result if Celexa withdrawal is done too quickly.
Understanding Celexa Withdrawal
A person taking Celexa may find the unwanted side effects of the drug to overshadow any perceived benefits of continuing to take the medication. Consequently, a decision may be made to stop taking Celexa. Except in the case of serotonin syndrome, a person should avoid stopping taking Celexa all at once or “cold turkey.” 27 To do so may introduce an overwhelming shock to the body, and may cause symptoms severe enough to require hospitalization and a lengthy protracted withdrawal.
Celexa withdrawal, side effects, and Celexa dependence can be better understood and managed within the greater context of how Celexa can alter brain chemistry, can disrupt CNS functions throughout the body, and can introduce physical and mental symptoms that can be debilitating. This article covers some information regarding Celexa withdrawal we hope you will find useful. If you are looking for information on safely stopping Celexa, we suggest you dive into these subjects on our website for more comprehensive information.
Safe Celexa withdrawal
A person may find that developed dependence on Celexa has begun to set in and that it would be best to stop taking Celexa before the situation worsens. It could be that the severity of Celexa’s side effects has begun to intensify, or has become intolerable. There can be many reasons to consider Celexa withdrawal treatment. A person taking Celexa will likely be experiencing a set of side effects already. An onslaught of a new set of Celexa withdrawal symptoms on top of earlier challenges could be completely overwhelming. Finding safe Celexa withdrawal help is recommended.
At Alternative to Meds Center, we aim to provide adequate preparations which stabilize a person before reducing the dosage. This prevents feeling completely bowled over by unexpected Celexa withdrawal symptoms. Without correct help, Celexa withdrawal symptoms may be severe enough to incapacitate a person, perhaps causing them to give up and resume their Celexa prescription. Because of the potential severity of withdrawal, we recommend inpatient Celexa withdrawal help to achieve a full and successful recovery of physical and mental health.
We are confident that with adequate preparation, including comprehensive guidance as to what to expect, Celexa withdrawal can be accomplished comfortably within a reasonably scheduled timeline. It is possible for a person to experience a surprisingly mild withdrawal from Celexa and other antidepressant drugs with careful oversight and planning. At Alternative to Meds, lab testing is done for toxicity, to discover what diet correction, including supplementation, may be needed to normalize neurochemistry. We also plan toxicity removal therapies, orthomolecular medicine for restoring a healthy microbiome, and other strategies to make citalopram withdrawal much easier to bear.
Holistic therapies used during and post-medically managed Celexa withdrawal include:
Transitioning to herbal medicines and micronutrients for anxiety, depression and insomnia, such as zinc, magnesium, passionflower extract, St. John’s wort, Omega-3 fatty acids, tryptophan/5HTP, glycine, taurine, and many others.40-44
WARNING:The FDA and other regulatory bodies warn against suddenly stopping Celexa or any antidepressant medication, due to the tremendous shock this can inflict on the body. What is recommended wherever possible is a gradual citalopram withdrawal as opposed to sudden cessation, or trying to quit Celexa “cold turkey.” With proper supports in place, a gradual citalopram withdrawal can be considerably eased.
Why are medications like Celexa called SSRIs?
Celexa is an SSRI medication. SSRI means selective serotonin reuptake inhibitor. Serotonin is a major regulating hormone affecting just about every area of human health, though it is most commonly thought of as the “happy chemical.” While there is a grain of truth to that, it’s a rather incomplete view because serotonin also regulates digestion, sleep, sexual function, body temperature, mammary glands, the liver, other organs, energy metabolism, the heart, and uncountable other functions.38 Celexa is called an SSRI antidepressant because it interrupts the normal transmission of serotonin. Drugmakers explain that this interruption is a good thing as it results in a build-up of serotonin.7 However, in pregnant women, faster metabolization rates show a reduced efficacy for SSRI medications, with unanswered questions concerning how this may relate to autism in the offspring.9 There are animal studies that indicate chronic use of SSRIs can actually create a serotonin deficit.8 A 2005 article published in PLOS Medicine talks at length about the disconnect between serotonin claims found in manufacturer direct-to-consumer advertising and what is discussed in the scientific literature.12
Tolerance is a condition where Celexa stops working and for a significant number of persons, long-term antidepressant use will not provide relief of their symptoms.13,14
Please remember that if, in fact, a serotonin deficiency does exist, there are many ways to alleviate a serotonin deficiency that are non-pharmacological.37
Do SSRIs like Celexa work for Major Depressive Disorder?
This type of serotonin-targeting antidepressant may have been prescribed without informing the patient what to expect, especially regarding the lack of evidence for long-term prescribing efficacy.10 A 2017 article published in BMC Psychiatry covering 131 clinical trials involving 27,422 participants discussed the value of treating Major Depressive Disorder (MDD) with SSRIs. They found that SSRIs might have statistically relevant effects on symptoms of depression, but that ALL of the reviewed trials “were at high risk of bias and the clinical significance seems questionable. SSRIs significantly increase the risk of both serious and non-serious adverse events. The potential small beneficial effects seem to be outweighed by harmful effects.” They went on to say “trials tend to overestimate benefits and underestimate harms. The ‘true’ effect of SSRIs might not even be statistically significant.”11 From what we have seen at Alternative to Meds Center, when other methods of holistic mental health care are available without medication side effects, most people tend to recover rapidly. This includes those who undergo Celexa withdrawal because the medication was not working and those who simply wanted to get pregnant or other reasons for stopping Celexa.
Researcher Paul Andrews, an assistant professor of Psychology, Neuroscience & Behaviour at McMaster published an article in a 2015 Neuroscience & Biobehavioral Reviews that claims that the improvement from an SSRI medication is likely a counter-reaction and an attempt to overcome antidepressant medication effects — that the body is trying to achieve balance despite the presence of the SSRI, rather than being assisted by the drug. He goes on to say that “instead of helping, the medications appear to be interfering with the brain’s own mechanisms of recovery.” 15
What do Celexa side effects feel like?
Initially, taking Celexa will begin to suspend (block) serotonin along the nerve channels, and this may produce a lift in tone or a degree of euphoria. These initial mood changes may be sudden or gradual but are temporary. It is not possible for any drug to create more serotonin. The effects are attained by manipulating or altering the rate of absorption and metabolism of natural neurochemicals such as serotonin. Drug effects are temporary because of several reasons, such as neuroadaptation, and depletion of natural hormones that degrade when not allowed to recycle as they normally would.15
All antidepressant drugs are more or less designed to lift depression in this way and can be effective for some for a time. However, other negative side effects frequently emerge and can range from moderate to severe.
Celexa side effects include: *
Suicidal thoughts, especially in persons under 25 years of age16
Depression that worsens18
Insomnia16
Nausea16
Weight loss or weight gain19
Confusion, cognitive disruption, inability to focus attention20
Sexual dysfunction16
Memory loss20
Abnormal Bleeding17
Hyponatremia17
Manic episodes17
Tiredness, drowsiness16
Headaches20
Shakiness16
Sweating20
Tachycardia (racing heartbeat) 20
Diarrhea, gas, cramps20
Tingling or numbness20
*See FDA Label for more details on Celexa side effects.
Side effects of Celexa also include the risk of upper gastrointestinal bleeding or abnormal bleeding in other areas of the body. These Celexa side effects are thought to be related to the adverse effects that Celexa can have on the coagulation of the blood. Mania is another Celexa side effect of concern. In Celexa drug trials where mania occurred in .2% of 1063 patients taking Celexa and in 0% of those in the 446 placebo group for the trial.16,22
What do I do if I am having Celexa Side Effects?
Some people may not experience severe or negative Celexa side effects, but when these do present they should be discussed with your primary caregiver, Precautions such as a reduction of dose, guided Celexa withdrawal, or other medical interventions can be initiated. Some patients may experience unpredictable changes in mood and behavior while taking Celexa. Such Celexa side effects can include a mix of both mental and physical manifestations. These may include suicidal thoughts, panic attacks, increased anxiety, and impulsive and aggressive feelings. Also reported are negative emotional reactions such as irritability, hostility, agitation, or feeling like hurting oneself.17,20 Physical side effects of Celexa may present as physical hyperactivity, muscle weakness, and a particularly troubling sensation of restlessness known as akathisia,21 from the Greek root, “akathemi,” which means to be unable to sit down or sit still. These symptoms can be relentless and impossible to tolerate.
What is Serotonin Syndrome?
Celexa (citalopram) and other SSRIs are linked with serotonin syndrome.16 Serotonin syndrome is a complex set of reactions that may include seizures, motor control dysfunction, respiratory impairment, potentially fatal rise in body temperature, tremors, blood pressure fluctuations, etc., and must be treated immediately due to the life-threatening implications of this drug-induced condition. Below you will find a more comprehensive list of serotonin syndrome signs to watch for.
Serotonin syndrome or other life-threatening reactions would be the ONLY case for immediate Celexa cessation, preferably in a hospital or emergency treatment setting.
More Information on Serotonin Syndrome — Signs to Watch For:
One very troubling side effect of taking Celexa, as with any serotonin-targeted medication, is the risk of a build-up of too much serotonin. This excessive build-up of serotonin can result in “serotonin syndrome.” This is a potentially life-threatening condition that requires immediate medical intervention including Celexa withdrawal. The remedy for this syndrome is, in part, to discontinue Celexa, but this must be done under strict monitoring and only in a medical facility that can provide immediate emergency treatment including the use of serotonin blockers, intravenous hydration, safe sedation, blood pressure stabilization, and other forms of life support that may be needed.
PLEASE NOTE: Serotonin Syndrome is one of the very few instances where the immediate cessation of Celexa is indicated. It is vital to provide support in a medical setting to save the life of the patient. Please note that gradual cessation is indicated in virtually every other scenario for safe Celexa withdrawal.
Signs of serotonin syndrome must be watched for as these require immediate medical intervention.
Serotonin Syndrome symptoms are considered life-threatening and are more likely to occur in overdose, shortly after starting to take Celexa, or when the dosage has been changed.*23-25
Signs of Serotonin Syndrome include:
Confusion
Muscle rigidity
Agitation
A rapid rise in body temperature
Fever
Hallucination/delirium
Diarrhea/cramps
Nausea
Vomiting
Loss of coordination
Restlessness
Heart palpitations
Seizure
Coma
Blood pressure fluctuations
*According to Mason et al.’s 2000 review of the subject, about 75% of serotonin syndrome cases happen within 24 hours of initiation or a change in dosage, or in overdose scenarios.
Medical advice for cases of serotonin syndrome will likely be to immediately stop taking Celexa and along with proper medical intervention, monitoring, and support in place, many of these reactions will usually begin to gradually abate over a number of days.26 However, some of these symptoms may persist for quite some time, even after Celexa withdrawal. In these cases, a lengthier period of medical treatment and sometimes hospitalization may be indicated.
Notes on Celexa Dependence
Of note, in a New Zealand study, about 27% of the group that was involved in the study felt they were either severely dependent, moderately dependent, or had a mild dependence on Celexa or similar medications. Those are quite significant numbers and show there is a potential problem.3 In the US, NBC News reported one in six Americans is taking antidepressants, and a study found that 60% of those on antidepressants continue taking them for more than 2 years.4 In the UK, it was reported in the British Medical Journal in 2018 that 12% of the British population was taking antidepressant medications and that the number of antidepressant prescriptions rose from 30 million in 2008 to 71 million in 2018.5
Clearly, Celexa dependence and developed dependence on other antidepressant drugs is a growing concern all over the world, and these soaring numbers show no sign of reversing. Many persons taking antidepressants as cited earlier, continue to take them because they feel the withdrawals are too severe to manage.
Where can I get more information on safe Celexa Withdrawal?
We can provide much more detailed information on request concerning all of the techniques and therapies used in our program at Alternative to Meds Center. Find out how each program component plays a significant role in the entire process. Our program is dedicated to helping you regain natural mental health using effective treatments for gentle and comfortable Celexa withdrawal so you can live life well, without the need to continue taking prescription medications.
“Over a lengthy course of 8 years, I was taking several different prescription drugs, including Lorazepam, Zoloft, Celexa (citalopram), Effexor, and Paxil, but finally, they were no longer working for me. I went with my husband to Alternative to Meds Center Where it was found that I had low Serotonin and heavy metal toxicity. After five weeks of being there, I’m feeling much, much better and I am off all the medications.” ~Viola
Questions relating to Celexa or citalopram are best directed to one’s prescribing physician, as patient history and health matters can differ greatly from one person to another. However, here are some of the most common questions that arise. It is always safest to seek medical advice from your primary caregiver whenever possible.
What is Celexa (citalopram) used for?
Celexa (citalopram) is approved to treat Major Depressive Disorder (MDD).
It is also given to patients suffering from a surprising number of other conditions, which is termed “off-label” prescribing.18,31 Off-label prescribing must be carefully considered especially when multiple drugs are prescribed, due to the number of drug-drug interactions that may result.32,34
Off-label uses for Celexa include:
Premenstrual dysphoric syndrome (PMDD)
Obsessive-Compulsive Disorder (OCD)
Generalized Anxiety Disorder (GAD)
Post-traumatic Stress Disorder (PTSD)
Social Anxiety Disorder
Panic Disorder
Anxiety disorders
Eating disorders
Bipolar Disorder
Are there patients who should avoid Celexa?
Yes. Celexa is NOT recommended for patients suffering from heart conditions such as long QT syndrome, slow heartbeat, irregular heartbeat, or for patients with magnesium deficiency, potassium deficiency, high blood pressure, patients at risk of or with a history of stroke, kidney disease, or liver disease. If liver injury or impairment occurs as a result of taking citalopram, the condition is largely considered reversible by discontinuing citalopram, but in some cases, the condition may be irreversible.31-33,35,39
Are there alternate names for Celexa (citalopram) around the world?
Yes, citalopram (the generic name) is sold under many different brand names in different countries, including:
Celexa in Canada and the US
Humorup in Argentina
Szetalo/Zetalo in India
Estar in Pakistan
Elopram in Italy
Citalex in Iran/Turkey
Citalo in Egypt
Celexa should not be confused with other similar-sounding drug names, or “look-alike” names, like Celebrex, Xanax, or Lexapro. The Institute for Safe Medication Practices (ISMP) recommends that a prescription label show both a drug’s brand name and the generic name, and also the purpose for the drug so as to reduce the risk of harm or accidental injury.2,3
Can I drink alcohol while taking Celexa?
Citalopram magnifies the effects of alcohol, and alcohol can conversely augment or alter the effects of medications. This can produce a host of negative effects, such as cognitive impairment, lack of clarity in perception, and impaired motor and muscle control. Therefore, driving a vehicle or operating heavy machinery while under the influence of alcohol is not recommended and this would be underscored if both alcohol AND Celexa were to be taken simultaneously. Because of their synergistic effects, there is a very real risk of overdose if too much alcohol is consumed while taking any SSRI medication. Overdose can result in respiratory shutdown, coma, and death.35 Therefore, it is safest to avoid mixing alcohol and Celexa. If you are not certain you can abstain from alcohol, seek medical advice from your primary health caregiver.5
Can Celexa cause weight loss or weight gain?
Yes, reports are clear that Celexa is linked to both weight loss and weight gain. Appetite can be suppressed in some persons resulting in weight loss. However, in other cases, Celexa results in increased appetite which can lead to weight gain. Some persons taking Celexa do not experience such effects on weight.
Is Celexa a benzodiazepine?
No. Celexa is an SSRI (Selective Serotonin Reuptake Inhibitor) type of antidepressant medication. Celexa targets serotonin, an inhibitory transmitter, and largely ignores other neurotransmitters such as dopamine or GABA. Benzodiazepine drugs primarily target and affect the inhibitory neurotransmitter called GABA, which is what results in the tranquilizing effects of the benzodiazepine class of drugs.36 Celexa is primarily targeting serotonin. Though the side effects of these two types of drugs may be similar. how they are thought to work is considered dissimilar.
Can Citalopram cause anxiety?
Yes, serotonin reuptake inhibitors (SSRIs) may increase anxiety symptoms, especially in the early phases of treatment. The study “A Single Dose of the Selective Serotonin Reuptake Inhibitor Citalopram Exacerbates Anxiety in Humans: A Fear-Potentiated Startle Study” 4 explored the idea that anxiety increased due to fear or anxiety about taking the drug, rather than anxiety being caused by the drug itself. However, the result of the study concluded that citalopram itself does exacerbate baseline anxiety levels, and therefore can cause or worsen anxiety in some individuals in early treatment. This phenomenon and other side effects may lead to the desire for Celexa withdrawal.
Can Celexa cause suicidal thinking?
Yes, according to the required FDA black box packaging label. The average risk of adverse events representing suicidal thinking or behavior (suicidality) during the first few months of treatment on Celexa and a host of other antidepressant drugs was double that of placebo in drug trials. Long-term use of the drug was not tested in any extended drug trials, so it is not known whether this risk increases over time.1
What is the best way to safely stop Celexa?
At Alternative to Meds Center, we use holistic measures to ensure the client weans off Celexa safely and comfortably. The whole process is overseen step by step in a fully-staffed in-patient setting. Clients are carefully monitored during Celexa withdrawal by a team of over 40 dedicated specialists, including physicians, nutrition-based therapists, and a wide array of holistic practitioners to enable a thorough, gentle, and health-restoring result.
18. Smith SW, Hauben M, Aronson JK. Paradoxical and bidirectional drug effects. Drug Saf. 2012 Mar 1;35(3):173-89. doi: 10.2165/11597710-000000000-00000. PMID: 22272687. [cited 2022 June 10]
20. Edinoff AN, Akuly HA, Hanna TA, Ochoa CO, Patti SJ, Ghaffar YA, Kaye AD, Viswanath O, Urits I, Boyer AG, Cornett EM, Kaye AM. Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review. Neurol Int. 2021 Aug 5;13(3):387-401. doi: 10.3390/neurolint13030038. PMID: 34449705; PMCID: PMC8395812. [cited 2022 June 10]
22. Peet M, Peters S. Drug-induced mania. Drug Saf. 1995 Feb;12(2):146-53. doi: 10.2165/00002018-199512020-00007. PMID: 7766338. [cited 2022 June 10]
23. Bartlett D. Drug-Induced Serotonin Syndrome. Crit Care Nurse. 2017 Feb;37(1):49-54. doi: 10.4037/ccn2017169. PMID: 28148614. [cited 2022 June 10]
24. Michigan University Medicine Serotonin syndrome May 28, 2019 Medical Review: Anne C. Poinier, MD – Internal Medicine & Kathleen Romito, MD – Family Medicine & Christine R. Maldonado, PhD – Behavioral Health. [cited 2022 June 10]
31. NAMI Citalopram (Celexa) Last Updated: January 2016. [cited 2022 June 10]
32. Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2023 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/ [cited 2024 April 30]
34. Jannini TB, Lorenzo GD, Bianciardi E, Niolu C, Toscano M, Ciocca G, Jannini EA, Siracusano A. Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs). Curr Neuropharmacol. 2022;20(4):693-712. doi: 10.2174/1570159X19666210517150418. PMID: 33998993. [cited 2022 June 10]
35. Park SH, Ishino R. Liver injury associated with antidepressants. Curr Drug Saf. 2013 Jul;8(3):207-23. doi: 10.2174/1574886311308030011. PMID: 23914755. [cited 2022 June 10]
36. Alshaimaa A. Elgarf, David C. B. Siebert, Friederike Steudle, Angelika Draxler, Guanguan Li, Shengming Huang, James M. Cook, Margot Ernst, and Petra Scholze Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors ACS Chem. Biol. 2018, 13, 8, 2033–2039 Publication Date: May 16, 2018. [cited 2022 June 10]
38. Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009;60:355-366. doi:10.1146/annurev.med.60.042307.110802 [cited 2022 June 10]
Diane is an avid supporter and researcher of natural mental health strategies. Diane received her medical writing and science communication certification through Stanford University and has published over 3 million words on the topics of holistic health, addiction, recovery, and alternative medicine. She has proudly worked with the Alternative to Meds Center since its inception and is grateful for the opportunity to help the founding members develop this world-class center that has helped so many thousands regain natural mental health.
Medical Disclaimer: Nothing on this Website is intended to be taken as medical advice. The information provided on the website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.
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A person may find that developed dependence on Celexa has begun to set in and that it would be best to stop taking Celexa before the situation worsens. It could be that the severity of Celexa’s side effects has begun to intensify, or has become intolerable. There can be many reasons to consider Celexa withdrawal treatment. A person taking Celexa will likely be experiencing a set of side effects already. An onslaught of a new set of Celexa withdrawal symptoms on top of earlier challenges could be completely overwhelming. Finding safe Celexa withdrawal help is recommended.
Celexa is an SSRI medication. SSRI means selective serotonin reuptake inhibitor. Serotonin is a major regulating hormone affecting just about every area of human health, though it is most commonly thought of as the “happy chemical.” While there is a grain of truth to that, it’s a rather incomplete view because serotonin also regulates digestion, sleep, sexual function, body temperature, mammary glands, the liver, other organs, energy metabolism, the heart, and uncountable other functions.38 Celexa is called an SSRI antidepressant because it interrupts the normal transmission of serotonin. Drugmakers explain that this interruption is a good thing as it results in a build-up of serotonin.7 However, in pregnant women, faster metabolization rates show a reduced efficacy for SSRI medications, with unanswered questions concerning how this may relate to autism in the offspring.9 There are animal studies that indicate chronic use of SSRIs can actually create a serotonin deficit.8 A 2005 article published in PLOS Medicine talks at length about the disconnect between serotonin claims found in manufacturer direct-to-consumer advertising and what is discussed in the scientific literature.12
Celexa (citalopram) and other SSRIs are linked with serotonin syndrome.16 Serotonin syndrome is a complex set of reactions that may include seizures, motor control dysfunction, respiratory impairment, potentially fatal rise in body temperature, tremors, blood pressure fluctuations, etc., and must be treated immediately due to the life-threatening implications of this drug-induced condition. Below you will find a more comprehensive list of serotonin syndrome signs to watch for.
